Rare Dermatology News
Acral peeling skin syndrome
Acral peeling skin syndrome is a genetic skin disorder characterized by painless peeling of the top layer of skin
Age of Onset
Acral peeling skin syndrome is a genetic skin disorder characterized by painless peeling of the top layer of skin. It is an autosomal recessive disorder characterized by lifelong peeling of the stratum corneum, and may be associated with pruritus, short stature, and anagen hair.
"Acral" refers to the fact that the peeling of the skin is most noticeable on the hands and feet of this state.†
5 Facts you should know
A genetic skin disorder characterized by painless peeling of the top layer of skin
The peeling is usually present from birth, but can appear later in childhood or early adulthood
Acral peeling skin syndrome can be caused by mutations in the TGM5 gene recessive pattern
Skin peeling is made worse by exposure to heat, humidity and other forms of moisture, and friction
There is no cure for acral peeling skin syndrome
Interest over time
Common signs & symptoms
Abnormal blistering of the skin
Flaking, peeling, scaly
There is no cure for acral peeling skin syndrome. Treatment is centered on preventing skin damage and addressing symptoms as they occur. Emollients are often used to reduce skin peeling. If blister develop, they may be lanced with a sterile needle. Light dressings should be applied to prevent infection. The condition may be made worse by hot temperatures, high humidity, and friction. Individuals with acral peeling skin syndrome should avoid these condition, when possible. Immersion in water should also be avoided.
Top Clinical Trials
At the time this analysis was conducted, there were no interventional clinical studies being conducted.
Top Treatments in Research
At the time this analysis was conducted, there were no treatments in development for this disease.
† Genetic and Rare Diseases Information Center (GARD) - PO Box 8126, Gaithersburg, MD 20898-8126 https://rarediseases.info.nih.gov